Onm-5: Evaluation of Patients with Ovarian Hyper Stimulation Syndrome and Medical Care in Infertility Treatment Course in Royan Research Center from 2010 to 2012

Background: Ovarian Hyper stimulation syndrome (OHSS) is infrequent and iatrogenic complication of ovary stimulation by Follicular stimulating hormone (FSH). OHSS is a probable complication of ovulation stimulating drugs, including clomiphene citrate and gonadotropins. Development of infertility treatment with the aim of reaching the desirable number of oocyte and embryo has led to ovary stimulation and increased pregnancy rates and risk of OHSS. On the basis of recent reports, the prevalence of short-term complications after infertility treatment is estimated 2%, which half on them is caused by OHSS.We performed this study is to evaluate the basic characteristic and treatment methods of OHSS patients Materials and Methods: This study has been designed as a cross-sectional study to assess demographic information, medical history and treatment protocols of patients that developed moderate or severe OHSS during infertility treatment cycles in Royan research center, Tehran, Iran; from January 2010 to January 2012.In this study we used census method to collect samples. Results: From 10000 referred patients to Royan research center, 261 patients (2.61%) developed OHSS. 101 (38.7%) of them had mild OHSS; 125 (47.8%) had moderate OHSS and 33 patients (12.6%) had severe OHSS and 2(0. 9%) had critical OHSS. 84.9% of patients had primary infertility. Mean of ovulation stimulation days was 9.9 in moderate cases and 10.31 in severe cases. (p=0.356). Totally, 18.8% of infertilities were caused by ovarian factors, 2.5% by fallopian factors, 49.4% by male factors, and 3.8 by unknown causes. Infertility type (primary vs. secondary), type of OHSS (early vs. late), history of EP and abortion, thyroid hormones, allergy and menstruation regulation were not different significantly between the moderate and severe/critical OHSS groups. Totally, 5.6% of cases undergo IUI, 70% ICSI and 24.4% IVF/ICSI. Conclusion: OHSS is a complication of ovulation. which can be life threatening. It is significantly more prevalent in young patients. Despite previous reports, PCOS and allergy did not correlate significantly with OHSS in this study.